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Amino-Functionalized Al−MOF for Fluorescent Detection of Tetracyclines in Milk
Summary:
The authors from Northwest A&F University, Ministry of Agriculture, and National Engineering Research Center of Agriculture Integration Test developed the (NH2)-MIL-53(Al) nanosensor with rich functional groups and high stability, achieving sensitive and rapid detection of tetracyclines (TCs) in milk.
Background:
1. TCs residues in milk threaten human health, but traditional detection methods (HPLC, LC-MS) are time-consuming and costly; existing fluorescent materials have defects like heavy metal risks and poor stability.
2. The authors proposed a one-pot hydrothermal synthesis strategy to prepare amino-functionalized Al-MOF, realizing synergistic fluorescence quenching via PET and IFE for efficient TCs detection.
Research Content:
1.Synthesis: Using (AlCl3·6H2O\) as the metal source and (NH2)-BDC as the ligand, the material was synthesized by one-pot hydrothermal method at 150 °C for 5 h.
2.Characterizations:
1) No BET/pore size data provided;
2) SEM showed uniform nanoplates with ~42.72 nm thickness;
3) UV-vis: absorption peaks at ~245 nm and 330 nm; FL: excitation 330 nm, emission 425 nm, quantum yield 49.17±2.1%.
3.Application: Detected TET, DOX, OTC in milk; linear ranges 0-72.33 μM, 0-66.67 μM, 0-86.67 μM; LOD 26.16 nM, 40.36 nM, 62.05 nM; recoveries 85.15-112.13%.
4.Mechanism: (NH2-COOH) of the material forms complexes with TCs via hydrogen bonding; electron transfer and 57-89% IFE synergistically induce fluorescence quenching.
Outlook:
This research provides a simple, sensitive, and low-cost method for TCs detection in food, enriching the application of functional MOFs in food safety testing.
Amino-Functionalized Al−MOF for Fluorescent Detection of Tetracyclines in Milk
Authors: Chunhua Li, Jianlong Wang, Li Zhu, Weixia Yang, Xie He, Sheliang Zhao, Xiaoshuo Zhang, Wenzhi Tang, Tianli Yue, Zhonghong Li
DOI: 10.1021/acs.jafc.8b06253
Link: https://pubs.acs.org/doi/10.1021/acs.jafc.8b06253
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