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Room-temperature controllable synthesis of hierarchically flower-like hollow covalent organic frameworks for brain natriuretic peptide enrichment
Summary:
The authors from Fuzhou University developed hierarchically flower-like hollow covalent organic frameworks (HFH-COFs) with high surface area and stability, achieving efficient enrichment of brain natriuretic peptide (BNP) from human serum.
Background:
1. To address the problem of low abundance and complex detection of BNP in human serum, previous researchers utilized various materials for enrichment but faced challenges such as poor selectivity and low sensitivity.
2. The authors proposed a room-temperature controllable synthesis method for HFH-COFs, achieving high uniformity, dispersibility, and crystallinity, which significantly enhanced BNP enrichment efficiency.
Research Content:
1. Synthesis:
The authors synthesized HFH-COFs using a room-temperature method by adjusting the proportion of water in the solvent and the concentration of acetic acid.
2. Characterizations:
1) BET results showed extremely high surface areas of 2276–2825 m² g⁻¹ with narrow pore size distribution at 2.73 nm.
2) SEM/TEM tests revealed uniform particle sizes ranging from 430 to 650 nm with a hollow, flower-like structure.
3) Other tests, including PXRD and FT-IR, confirmed the crystallinity and successful formation of the COFs.
3. Application:
The HFH-COFs loaded with gold nanoparticles (HFH-COF-1@Au) were tested for BNP enrichment, achieving detection limits as low as 0.02 fmol mL⁻¹ in human serum.
4. Mechanism:
The formation of HFH-COFs was explained by the Ostwald ripening theory, where inner crystallites dissolved and reassembled on the outer surface, forming a hollow structure. This structure facilitated efficient BNP capture through strong Au–thiolate interactions.
Outlook:
This research provides a novel approach for the controllable synthesis of HFH-COFs at room temperature, significantly enhancing the enrichment and detection of ultralow-abundance BNP in complex biological samples. The findings open new avenues for the application of COFs in clinical diagnostics.
Room-temperature controllable synthesis of hierarchically flower-like hollow covalent organic frameworks for brain natriuretic peptide enrichment
Authors: Wende Ma, Guorong Li, Chao Zhong, Yixin Yang, Qianqian Sun, Dan Ouyang, Wei Tong, Wenchang Tian, Lan Zhang, Zian Lin
DOI: 10.1039/d1cc02646a
Link:
https: https://pubs.rsc.org/en/content/articlelanding/2021/cc/d1cc02646a
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