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Specific Nanodrug for Diabetic Chronic Wounds Based onAntioxidase-Mimicking MOF-818 Nanozymes
Summary:
The authors from the Changchun Institute of Applied Chemistry and Jilin University developed a MOF-818 nanozyme-based hydrogel with antioxidant enzyme-like activity, achieving significant results in the treatment of diabetic chronic wounds.
Background:
1. Diabetic chronic wounds are characterized by prolonged inflammation and oxidative stress, leading to delayed healing. Previous treatments using natural antioxidant enzymes faced challenges such as poor stability and bioavailability.
2. The authors proposed an innovative method by integrating MOF-818 nanozymes with a thermosensitive hydrogel to create an antioxidative system (MOF/Gel), obtaining promising results in wound healing.
Research Content:
1. Synthesis:
The authors synthesized MOF-818 through a solvothermal method and combined it with a PLGA-PEG-PLGA hydrogel to form the MOF/Gel system.
2. Characterizations:
1) BET analysis showed a high surface area of 1314 m²/g and a pore size distribution centered at 2.18 nm.
2) SEM/TEM tests revealed octahedral MOF-818 nanoparticles with an average size of 195 nm.
3) UV-vis and EPR tests confirmed the SOD- and CAT-like activities of MOF-818.
3. Application:
The MOF/Gel system was tested on diabetic rat wounds, showing comparable efficacy to human epidermal growth factor gel (HEGFG) with only one-time application.
4. Mechanism:
The MOF-818 nanozymes effectively scavenged ROS, modulated the oxidative stress microenvironment, and promoted the transition from inflammation to proliferation phases in wound healing.
Outlook:
This research demonstrates the potential of MOF nanozymes in diabetic wound healing, providing a convenient, safe, and effective alternative to traditional treatments. The MOF/Gel system shows great promise for clinical applications.
Specific Nanodrug for Diabetic Chronic Wounds Based on Antioxidase-Mimicking MOF-818 Nanozymes
Authors: Daiyong Chao, Qing Dong, Zhixuan Yu, Desheng Qi, Minghua Li, Lili Xu, Ling Liu, Youxing Fang, Shaojun Dong
DOI: 10.1021/jacs.2c09663
Link: https://pubs.acs.org/doi/10.1021/jacs.2c09663
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